View Challenges

Displaying 1 - 10 of 21
In progress
2015
Objective To develop in vitro / in silico assay(s) that can be used singly or in combination to improve risk assessment for GT products. These assays should be applicable to the assessment of a wide range...
In progress
2015
  Objective To establish, both qualitatively (which metabolites are produced) and quantitatively (concentration of the metabolites produced), the extent to which skin metabolism determines xenobiotic...
Complete
2014
To use existing toxicological data repositories to develop in silico tools which can be used to predict toxicology endpoints for substances of interest in order to waive in vivo studies.
2014
To develop novel approaches to address the potential human safety issues arising from chemicals interacting with ‘off-target’ receptors.
In progress
2014
To generate physiologically-relevant human stem cell-based model(s) to identify neurotoxicity (neuronal viability/functional impairment).
In progress
2013
To develop a virtual platform that models infection and the host response to pathogen assault for basic research and enhances new target development in infectious diseases.
In progress
2013
To develop a multi-compartmental, microfluidic tissue assay that models the renal tubular injury observed in nephrotoxicity. 
In progress
2013
To enable the longitudinal and non-invasive assessment of inflammation and FM toxicity in the same animal through a series of dose-escalation stages.
In progress
2013
To generate a physiologically-relevant in vitro cardiac contractility platform.
In progress
2013
To develop a physiologically relevant human stem cell-derived neuronal assay to predict the efficacy and unexpected pharmacological effects of new chemical entities targeting tau in Alzheimer’s disease.

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